COMPLEMENTARY FEEDS

NATURAL ACTIVE

It is a product made of vegetal extracts to have a good gut microflora balance in monogastric animals and, as a consequence, it helps animal welfare.

Natural Active as feed integration is one way to maintain good gut microflora balance, in fact thanks to its formulation (made with vegetable extracts, pectins and toasted cereals) it is a good substrate for gut microflora, also in such difficult conditions such as intensive livestock growing.

Natural Active, with its special formulation, has several complementary actions. Pectins can absorb water and therefore regulate the consistence of faeces both in case of diarrhea or constipation, and they represent a good substrate for the growth of beneficial microflora .

Vegetable extracts have a good adsorbent and astringent effect, and they can contribute to reducing the smell of manure.

Toasted cereals have an excellent protective property for gut walls and represent a good substrate for microflora.

We can conclude that Natural Active can protect the gut mucosa and as a consequence we have an improvement in nutrient assimilation and an enhanced production of short chain fatty acids and a good antidiarrhoeal effect.

References: De Roos N.M et at “Effects of probiotic bacteria on diarrea, lipid metabolism and carcinogenesis” Am.J.Clin. Nutr. 71(2) 405-411. 2000 Lene Lind Mikkelsen,1* Patrick J. Naughton,2 Mette S. Hedemann,1 and Bent Borg Jensen1 Danish Institute of Agricultural Sciences, Research Centre Foulum, DK-8830 Tjele, Denmark,1 Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster (at Coleraine), Coleraine, County Londonderry BT52 1SA, United Kingdom2 “Effects of Physical Properties of Feed on Microbial Ecology and Survival of Salmonella enterica Serovar Typhimurium in the Pig Gastrointestinal Tract” Applied and Environmental Microbiology, June 2004, p. 3485-3492, Vol. 70, No. 6 L E M Willemsen, M A Koetsier S J H van Deventer E A F van Tol (1Numico Research BV, Wageningen, the Netherlands, Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands) “Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts” Gut 2003;52:1442-1447 doi: 10.1136/gut.52.10.1442 Rowland, IR ”Reduction by the gut microflora of animals and man”. Biochemical Pharmacology [BIOCHEM. PHARMACOL.]. Vol. 35, no. 1, pp. 27-32. 1986. Andrew J. Macpherson1 & Nicola L. Harris1 About the authors “Interactions between commensal intestinal bacteria and the immune system” Nature Reviews Immunology 4, 478-485 (June 2004) | doi:10.1038/nri1373

TECHNOLOGICAL ADDITIVES - ACIDIFIERS

SHORTACID

It is Eurofeed’s new product for swine, poultry and rabbits.

It contains Ester of butyric acid and other acidifiers.

Esters of butyric acid is a prompt source of energy for intestinal cells, it helps to protect intestinal cells integrity, very important in the first days of life for all animals. It can act in the gut because the ester-bond is broken by pancreatic lipase and so butyric acid can be present in the gut directly. Esters of butyric acid has not any problem of taste and smell, as a difference from butyric acid.

This product is above all for little animals of all species.

Weaning piglets, chicks, weaning rabbits: It helps animal in the first part of their life to outgo the intestinal problems due to change of alimentation and infection, often present in this period.

In world scietific literature "nutraceutical properties" for butyric acid are reported. The ester bond (ester of butyric acid) is broken by pancreatic lipase and free butyric acid in the first part of the gut is a promt source of energy for gut cells and it helps to protect enterocytes in their growth and functions. glycerides of butyric acid and butyric acid itself have important antimicrobials properties too.  Swine: Sakata T. "stimulatory effect of short chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanationfor trophic effects of fermentable fiber, gut microbes and luminal trophic factors. British journal of Nutrition, 1987, 58, pp 95-103. Antongiovanni M., Buccioni A., Petacchi F., LEESON S., MINIERI S., MARTINI A., CECCHI R. (2007) Butyric acid glicerides in the diet of broiler chickens: effects on gut histology and carcass composition. Italian Journal of Animal Science 6, 19-25. Close W. H. (2000) Producing pigs without antibiotic growth promoters. Advances in Pork Production, 49–56. Galfi P. & Bokori J. (1990) Feeding trial in pigs with a diet containing sodium n-butyrate. Acta Veterinaria Hungarica 38, 3-17. Leeson S., Namkung H., Antongiovanni M. & Lee E. (2005) Effect of butyric acid on the performance and carcass yield of broiler chickens. Poultry Science 84, 1418. Mroz. (2005) Organic acids as potential alternatives to antibiotic growth promoters for pigs. Advances in Pork Production 16, 169-182. Roselli M., Finamore A., Britti M. S., Bosi P., Oswald I. & Mengheri E. (2005) Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. Animal Research 54, 203-218. Topping D. L. (1996) Short-chain fatty acids produced by intestinal bacteria. Asia Pacific Journal of Clinical Nutrition 5, 15-19. Uzzau S. Fasano A. (2000) Cross-talk between enteric pathogens and the intestine. Cellular Microbiology 2, 83-89. Poultry: F Van Immerseel, F Boyen, I Gantois, L Timbermont, L Bohez, F Pasmans, F Haesebrouck, and R Ducatelle. Supplementation of coated butyric acid in the feed reduces colonization and shedding of Salmonella in poultry. Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Belgium. UGent C. Fernandez-Rubio, C. Ordonez, J. Abad-Gonzalez, A. Garcia-Gallego, M. P. Honrubia, J. J. Mallo, and R. Balana-Fouce. Butyric acid-based feed additives help protect broiler chickens from Salmonella Enteritidis infection. Poult. Sci., May 1, 2009; 88(5): 943 - 948. N. Nakanishi, K. Tashiro, S. Kuhara, T. Hayashi, N. Sugimoto, and T. Tobe Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli. Microbiology, February 1, 2009; 155(2): 521 - 530.